Sep 4, 2025; Milwaukee, Wisconsin, USA; Milwaukee Brewers starting pitcher Freddy Peralta (51) reacts after striking out Philadelphia Phillies third baseman Alec Bohm (not pictured) with the bases loaded in the fourth inning at American Family Field. Mandatory Credit: Benny Sieu-Imagn Images The Monday MLB card of three games holds plenty of player and team props to choose from. The game of the night takes place at Petco Park as the San Diego Padres host the Milwaukee Brewers in an NL battle between playoff teams.
We’ll break down three plays for the Monday action. Remember to monitor the odds throughout the day, as the props and totals market is constantly changing.
Here are the free MLB picks for Monday, September 22.
Best MLB Picks September 22nd
Nationals F5 at Braves (+195)
Cardinals F5 at Giants (+124)
Freddy Peralta Over 5.5 K’s (+109)
Nationals F5 at Braves (+195 at DraftKings)
The Atlanta Braves return home from a perfect 7-0 road trip as they host the Washington Nationals.
The Braves pulled off a four-game sweep of the Nationals to begin the trip as they send Chris Sale to the mound tonight.
Sale has led through five innings only once in his four starts since coming off the IL.
The Nats took the final two games of their series against the Mets, as left-hander MacKenzie Gore gets the start.
Gore has trailed through five innings in two of his last six starts, while tossing 5.1 scoreless innings against Atlanta last Tuesday.
The Braves are 4-11 in their last 15 home games in the first five innings.
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Cardinals F5 at Giants (+124 at FanDuel)
The San Francisco Giants return home after avoiding a four-game sweep to the Los Angeles Dodgers on Sunday.
The Cardinals head west after taking two of three from the Brewers this past weekend. St. Louis grabbed two of three from San Francisco at Busch Stadium earlier this month.
Michael McGreevy heads to the hill for the Redbirds, who owns a spectacular 10-3-1 record in the first five innings this season.
Justin Verlander has pitched well of late, not allowing a run in the first five innings in his past four starts. The Giants have not led through five innings in nine straight games.
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Freddy Peralta Over 5.5 Strikeouts (+109 at DraftKings)
The Brewers face the Padres tonight in San Diego as Milwaukee has already wrapped up the NL Central title.
Freddy Peralta has hit the Over on his strikeout prop in seven of his last eight starts. The Milwaukee right-hander has posted six K’s or more during each one of those outings, including 10 strikeouts against the Angels in his most recent start.
The last time Peralta started against the Padres back in June, he was limited to three strikeouts.
In the past 25 games, opposing pitchers have gone Over their K prop 17 times when facing the Padres.
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